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WHO Grade 2 Astrocytoma

Gross brain (left) and corresponding axial contrast-enhanced CT (right). Notice that the right hemisphere is grossly enlarged, but without a focal lesion. There is a diffuse infiltration of the right hemisphere by a low-grade (WHO Grade 2) fibrillary astrocytoma. This appearance is typical of the so-called "gliomatosis cerebri". Notice that although the right thalamus is slightly enlarged (displacement of the internal cerebral veins to left) there is no abnormal enhancement. A lack of enhancement is typical for low-grade diffuse astrocytomas.